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Jaundice due to carbimazole.

Authors
  • Lunzer, M
  • Huang, S N
  • Ginsburg, J
  • Ahmed, M
  • Sherlock, S
Type
Published Article
Journal
Gut
Publication Date
Nov 01, 1975
Volume
16
Issue
11
Pages
913–917
Identifiers
PMID: 1193420
Source
Medline
Language
English
License
Unknown

Abstract

On three occasions, a 63 year old housewife with hyperthyroidism developed a reaction which included fever, pruritus, malaise, and, on one occasion, jaundice one to 17 days after taking carbimazole. Challenge with carbimazole was followed within 12 hours by abdominal pain, pruritus, and increased serum transaminase levels. Light microscopy of a liver biopsy showed increase of portal zone cellularity over the control and the electron microscopy revealed fine structural changes compatible with drug-related liver injury.

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