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The Janus kinase 1/2 inhibitor baricitinib reduces biomarkers of joint destruction in moderate to severe rheumatoid arthritis

Authors
  • Thudium, Christian S.1
  • Bay-Jensen, Anne C.1
  • Cahya, Suntara2
  • Dow, Ernst R.2
  • Karsdal, Morten A.1
  • Koch, Alisa E.2
  • Zhang, Wenling2
  • Benschop, Robert J.2
  • 1 Nordic Bioscience, Biomarkers and Research, Herlev Hovedgade 205-207, Herlev, DK-2730, Denmark , Herlev (Denmark)
  • 2 Eli Lilly and Company, Indianapolis, Indiana, USA , Indianapolis (United States)
Type
Published Article
Journal
Arthritis Research & Therapy
Publisher
Springer Science and Business Media LLC
Publication Date
Oct 12, 2020
Volume
22
Issue
1
Identifiers
DOI: 10.1186/s13075-020-02340-7
Source
Springer Nature
Keywords
License
Green

Abstract

BackgroundTissue released blood-based biomarkers can provide insight into drug mode of action and response. To understand the changes in extracellular matrix turnover, we analyzed biomarkers associated with joint tissue turnover from a phase 3, randomized, placebo-controlled study of baricitinib in patients with active rheumatoid arthritis (RA).MethodsSerum biomarkers associated with synovial inflammation (C1M, C3M, and C4M), cartilage degradation (C2M), bone resorption (CTX-I), and bone formation (osteocalcin) were analyzed at baseline, and weeks 4 and 12, from a subgroup of patients (n = 240) randomized to placebo or 2-mg or 4-mg baricitinib (RA-BUILD, NCT01721057). Mixed-model repeated measure was used to identify biomarkers altered by baricitinib. The relationship between changes in biomarkers and clinical measures was evaluated using correlation analysis.ResultsTreatment arms were well balanced for baseline biomarkers, demographics, and disease activity. At week 4, baricitinib 4-mg significantly reduced C1M from baseline by 21% compared to placebo (p < 0.01); suppression was sustained at week 12 (27%, p < 0.001). Baricitinib 4-mg reduced C3M and C4M at week 4 by 14% and 12% compared to placebo, respectively (p < 0.001); they remained reduced by 16% and 11% at week 12 (p < 0.001). In a pooled analysis including all treatment arms, patients with the largest reduction (upper 25% quartile) in C1M, C3M, and C4M by week 12 had significantly greater clinical improvement in the Simplified Disease Activity Index at week 12 compared to patients with the smallest reduction (lowest 25% quartile).ConclusionBaricitinib treatment resulted in reduced circulating biomarkers associated with joint tissue destruction as well as concomitant RA clinical improvement.Trial registrationClinicalTrials.gov NCT01721057; date of registration: November 1, 2012

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