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Jagged1 protein enhances the differentiation of mesenchymal stem cells into cardiomyocytes.

Authors
Type
Published Article
Journal
Biochemical and biophysical research communications
Publication Date
Volume
341
Issue
2
Pages
320–325
Identifiers
PMID: 16413496
Source
Medline
License
Unknown

Abstract

MSCs can differentiate into cardiomyocytes in vitro and in vivo if a cardiomyocyte microenvironment is provided. 2. Cell-to-cell interaction is very important for the differentiation of MSCs into cardiomyocytes. 3. Jagged1 protein can activate Notch signal and enhance the differentiation of MSC into cardiomyocyte, while the effect can be inhibited by DAPT.

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