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Isoxazoline GPIIb/IIIa antagonists bearing a phosphoramidate.

Authors
  • Wityak, J
  • Tobin, A E
  • Mousa, S A
  • Wexler, R R
  • Olson, R E
Type
Published Article
Journal
Bioorganic & Medicinal Chemistry Letters
Publisher
Elsevier
Publication Date
Jan 18, 1999
Volume
9
Issue
2
Pages
123–126
Identifiers
PMID: 10021912
Source
Medline
License
Unknown

Abstract

Isoxazolinylacetamides bearing a phosphoramidate group alpha- to the carboxylate moiety (3) were prepared and evaluated for in vitro antiplatelet efficacy. They were found to bind GPIIb/IIIa with high affinity and were potent antagonists of ADP mediated platelet aggregation.

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