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[Isolation and study of the biological properties of substances stimulating levorin biosynthesis in a mixed actinomycete and yeast culture].

Authors
  • Iakovleva, E P
  • Alekseeva, L E
Type
Published Article
Journal
Antibiotiki i meditsinskaia biotekhnologiia = Antibiotics and medical biotechnology / Ministerstvo meditsinskoĭ promyshlennosti SSSR
Publication Date
Nov 01, 1986
Volume
31
Issue
11
Pages
830–835
Identifiers
PMID: 3545067
Source
Medline
License
Unknown

Abstract

Active components responsible for increased synthesis levels of levorin, a polyenic antibiotic in mixed cultures of an actinomycete and a yeast-like fungus C. tropicalis were isolated from the fermentation broth. Component I identified as succinic acid increased the levels of the antibiotic production by 40-50 per cent. Component II found to be lactic acid increased the antibiotic production levels by 20 per cent. Component III, a mixture of nonidentified substances of the amine nature stimulated biosynthesis of levorin by 20-25 per cent. Addition of a mixture of succinic acid and N-methyl glucosamine to the nutrient medium provided increase of the antibiotic activity of the fermentation broth up to 175-185 per cent as compared to the control.

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