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Isolation and purification of a small peptide with activity of increasing E-receptor expression from calf thymus.

Authors
Type
Published Article
Journal
Immunological investigations
Publication Date
Volume
14
Issue
4
Pages
355–365
Identifiers
PMID: 3877684
Source
Medline

Abstract

A small peptide of molecular mass lower than 1,000 daltons was isolated and purified from a crude extract of calf thymus. It has been demonstrated to have the activity of increasing E-rosette formation and E-receptor expression of human and porcine T-lymphocytes with three different in vitro assays. Amino acid composition analysis showed that this peptide consists of glutamic acid, aspartic acid and glycine residues at a molecular ratio of 3:3:2. A hypothesis of a multi-factoral and multi-staged mechanism of regulation of thymocyte differentiation and maturation in the thymus is proposed.

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