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Isolation and molecular characterization of a urease-negative Actinobacillus pleuropneumoniae mutant.

Authors
  • Ito, Hiroya1, 2, 3, 4, 5
  • Takahashi, Sayaka1, 2, 3, 4, 5
  • Asai, Tetsuo1, 2, 3, 4, 5
  • Tamura, Yutaka1, 2, 3, 4, 5
  • Yamamoto, Koshi1, 2, 3, 4, 5
  • 1 The National Institute of Animal Health, National Agriculture and Food Research Organization, Tsukuba, Ibaraki, Japan (Ito). , (Japan)
  • 2 Zen-Noh Institute of Animal Health, Sakura, Chiba, Japan (Takahashi). , (Japan)
  • 3 Gifu University, Gifu, Gifu, Japan (Asai). , (Japan)
  • 4 Rakuno Gakuen University, Ebetsu, Hokkaido, Japan (Tamura). , (Japan)
  • 5 Tokyo University of Agriculture, Tokyo, Japan (Yamamoto). , (Japan)
Type
Published Article
Journal
Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc
Publication Date
Nov 01, 2017
Identifiers
DOI: 10.1177/1040638717742436
PMID: 29145759
Source
Medline
Keywords
License
Unknown

Abstract

An atypical urease-negative mutant of Actinobacillus pleuropneumoniae serovar 2 was isolated in Japan. Nucleotide sequence analysis of the urease gene cluster revealed that the insertion of a short DNA sequence into the cbiM gene was responsible for the urease-negative activity of the mutant. Veterinary diagnostic laboratories should be watchful for the presence of aberrant urease-negative A. pleuropneumoniae isolates.

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