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Isolation and identification of two new compounds from the twigs and leaves of Cephalotaxus fortunei

Authors
  • Feng, Qingmei
  • Li, Bingxin
  • Feng, Yuan
  • Li, Xingyu
  • Ma, Xiaorui
  • Wang, Haifeng
  • Chen, Gang
Type
Published Article
Journal
Journal of Natural Medicines
Publisher
Springer Singapore
Publication Date
Apr 11, 2019
Volume
73
Issue
3
Pages
653–660
Identifiers
DOI: 10.1007/s11418-019-01308-5
Source
Springer Nature
Keywords
License
Yellow

Abstract

Two new compounds, namely 5-hydroxy-7-methoxy-6-methylchromone (1), and sesquiterpene X (6), together with 21 known compounds were isolated from the twigs and leaves of Cephalotaxus fortunei Hook. f. The structures of 1–23 were elucidated on the basis of spectroscopic analysis (1D/2D NMR, HR-ESI–MS and IR) and comparison with literature. The absolute configuration of compound 6 was determined by means of electronic circular dichroism calculation. The in vitro anti-inflammatory activities of all compounds were assayed in RAW 264.7 cells by assessing lipopolysaccharide-induced nitric oxide production. Compounds 1 and 6 exhibited weak effects with percentage inhibitions of 24% and 35.60%, respectively. In addition, compounds 4, 9, and 14 have the potential to be developed as therapeutic agents for inflammatory diseases because of their significant anti-inflammatory activities and high content in C. fortunei.

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