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Isolation and identification of the major metabolite of albuterol in human urine.

Authors
Type
Published Article
Journal
Drug metabolism and disposition: the biological fate of chemicals
Publication Date
Volume
5
Issue
3
Pages
234–238
Identifiers
PMID: 17520
Source
Medline

Abstract

The major urinary metabolite of albuterol in man was isolated and purified by ion-exchange chromatography and countercurrent distribution. On the basis of proton magnetic resonance, infrared, and mass-spectral analysis, enzymic hydrolysis, and assay of inorganic sulfate after acid hydrolysis, the metabolite has been identified as the 4'-O-sulfate ester of albuterol.

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