Isolation of Hafnia paralvei co-harbouring blaNDM-1 and blaVIM-1 in a woman who underwent allogeneic hematopoietic stem cell transplantation.

Tobias Manuel Appel; Claudia Stein; Christian Brandt; Jürgen Rödel; Jochen J Frietsch; Jenny Miethke; Andreas Hochhaus; Inken Hilgendorf

doi:10.1007/s15010-022-01976-8

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Isolation of Hafnia paralvei co-harbouring blaNDM-1 and blaVIM-1 in a woman who underwent allogeneic hematopoietic stem cell transplantation.

Authors

Appel, Tobias Manuel^{1, 2}
Stein, Claudia³
Brandt, Christian³
Rödel, Jürgen⁴
Frietsch, Jochen J⁵
Miethke, Jenny⁵
Hochhaus, Andreas⁵
Hilgendorf, Inken⁵

¹ Klinik für Innere Medizin II, Abteilung für Hämatologie und internistische Onkologie, Universitätsklinikum Jena, Kastanienstraße 1, 07747, Jena, Germany. [email protected]. , (Germany)
² Medizinische Klinik 2, Infektiologie, Universitätsklinikum Frankfurt, Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Germany. [email protected]. , (Germany)
³ Institut für Infektionsmedizin und Krankenhaushygiene, Universitätsklinikum Jena, Kastanienstraße 1, 07747, Jena, Germany. , (Germany)
⁴ Institut für Medizinische Mikrobiologie, Universitätsklinikum Jena, Kastanienstraße 1, 07747, Jena, Germany. , (Germany)
⁵ Klinik für Innere Medizin II, Abteilung für Hämatologie und internistische Onkologie, Universitätsklinikum Jena, Kastanienstraße 1, 07747, Jena, Germany. , (Germany)

Type

Published Article

Journal

Infection

Publisher

Springer-Verlag

Publication Date

Aug 01, 2023

Volume

51

Issue

4

Pages

1161–1164

Identifiers

DOI: 10.1007/s15010-022-01976-8

PMID: 36595211

Source

Medline

Keywords

Language

English

License

Unknown

Abstract

Metallo-β-lactamases (MBL) are a threat to public health, since they dramatically limit the use of β-lactams. We report the isolation of a multidrug-resistant Hafnia paralvei strain from urine and a rectal swab of a female patient after allogeneic hematopoietic stem cell transplantation for myelodysplastic syndrome. Antimicrobial susceptibility testing yielded resistance to trimethoprim/sulfamethoxazole, colistin, fosfomycin and all β-lactams, except cefiderocol. Whole genome sequencing revealed the presence of plasmid-encoded NDM-1 and VIM-1 carbapenemases. This finding highlights the importance of epidemiological surveillance and new therapeutic options for MBL. © 2023. The Author(s).

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. This record was last updated on 07/27/2023 and may not reflect the most current and accurate biomedical/scientific data available from NLM. The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/36595211

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