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Isolation, detection, and immunomorphological characterization of circulating tumor cells (CTCs) from patients with different types of sarcoma using isolation by size of tumor cells: a window on sarcoma-cell invasion.

Authors
  • Chinen, Ludmilla T Domingos
  • Mello, Celso A Lopes
  • Abdallah, Emne Ali
  • Ocea, Luciana Mm
  • Buim, Marcilei E
  • Breve, Natália M
  • Gasparini, José Luiz Junior
  • Fanelli, Marcello F
  • Paterlini-Bréchot, Patrizia
Type
Published Article
Journal
OncoTargets and Therapy
Publisher
Dove Medical Press
Publication Date
Jan 01, 2014
Volume
7
Pages
1609–1617
Identifiers
DOI: 10.2147/OTT.S62349
PMID: 25258541
Source
Medline
Keywords
License
Unknown

Abstract

This study shows the feasibility of isolating, identifying, and characterizing CTCs from patients with different types of sarcomas and the presence of circulating sarcoma cells in all the tested patients. Our results set the basis for further studies aimed at exploring the presence, number, and immunomolecular characteristics of CTCs in different types of sarcoma, and bring more light to the mechanisms of tumor invasion for these tumors.

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