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Isolation and characterization of new anti-HIV and cytotoxic leads from plants, marine, and microbial organisms.

Authors
  • McKee, T C1
  • Bokesch, H R
  • McCormick, J L
  • Rashid, M A
  • Spielvogel, D
  • Gustafson, K R
  • Alavanja, M M
  • Cardelline, J H 2nd
  • Boyd, M R
  • 1 Laboratory of Drug Discovery Research and Development, National Cancer Institute, Frederick, Maryland 21702-1201, USA.
Type
Published Article
Journal
Journal of natural products
Publication Date
May 1997
Volume
60
Issue
5
Pages
431–438
Identifiers
PMID: 9170286
Source
Medline
License
Unknown

Abstract

New cytotoxic isomalabaricane triterpenes have been isolated from a sponge Stelletta sp. (1-7); anti-HIV pterocarpans (8 and 9) and isoflavanoids (12-16 and 18) were elucidated from two tropical plants in the genus Erythrina; and anti-HIV enniatins (20 and 22-23) were characterized from fungi in the genera Fusarium and Alternaria. The enniatins were evaluated for in vivo anti-HIV activity in the hollow fiber assay.

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