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Isolation and characterization of simian virus 40 early region deletion mutants.

Authors
  • L M Sompayrac
  • K J Danna
Publication Date
Jul 01, 1982
Source
PMC
Keywords
License
Unknown

Abstract

We constructed a tsB4/dl884 double-mutant helper virus and used it to isolate two simian virus 40 early region deletion mutants that lack about half of the DNA sequences normally used to encode the large tumor antigen (T). Both mutants make a normal-sized small t antigen, but neither mutant can replicate its DNA in the absence of a T+ helper.

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