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Isolated lymphadenitis due to Histoplasma capsulatum diagnosed by fine-needle aspiration biopsy and immunohistochemistry

  • TUON, Felipe F.
  • GOMES, Vivian
  • PAGLIARI, Carla
  • CTENAS, Bruno B.
  • MOSCOSO, Patricia Carrasco Flores de
  • GERHARD, Rene
  • KANASHIRO, Luciane
  • BRASIL, Roosecelis A.
  • DUARTE, Maria Irma Seixas
Publication Date
Jan 01, 2008
Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (BDPI/USP)
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In the disseminated form of histoplasmosis, isolation and further identification of Histoplasma capsulatum can be performed by several methods, namely, bone marrow aspiration, blood culture, and liver biopsy. Lymph node disease usually is diagnosed by excisional biopsy. Although fungal stains can identify this fungus, detection of specific antigens by immunohistochemistry shows a higher specificity and sensitivity. This approach can use the cell block method when the material is not sent to fungal cultures or fresh staining.


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