The structures of isochromophilones I and II, new gp120-CD4 binding inhibitors isolated from a cultured broth of Penicillium multicolor FO-2338, were elucidated by NMR experiments. Both of compounds have an azaphilone skeleton substituted by a chlorine atom at C-5 and a side chain, 3,5-dimethyl-1,3-heptadien at C-3. Additionally, isochromophilone I has a gamma-lactone ring, and isochromophilone II has 2-oxopropyl moiety instead of a gamma-lactone ring.
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
This record was last updated on 07/02/2016 and may not reflect the most current and accurate biomedical/scientific data available from NLM.
The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/7649872