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Isochromophilones I and II, novel inhibitors against gp120-CD4 binding produced by Penicillium multicolor FO-2338. II. Structure elucidation.

Authors
  • Matsuzaki, K
  • Tanaka, H
  • Omura, S
Type
Published Article
Journal
The Journal of antibiotics
Publication Date
Jul 01, 1995
Volume
48
Issue
7
Pages
708–713
Identifiers
PMID: 7649872
Source
Medline
License
Unknown

Abstract

The structures of isochromophilones I and II, new gp120-CD4 binding inhibitors isolated from a cultured broth of Penicillium multicolor FO-2338, were elucidated by NMR experiments. Both of compounds have an azaphilone skeleton substituted by a chlorine atom at C-5 and a side chain, 3,5-dimethyl-1,3-heptadien at C-3. Additionally, isochromophilone I has a gamma-lactone ring, and isochromophilone II has 2-oxopropyl moiety instead of a gamma-lactone ring.

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