Affordable Access

deepdyve-link deepdyve-link
Publisher Website

Ischaemia-reperfusion injury in liver transplantation--from bench to bedside.

Authors
  • Zhai, Yuan
  • Petrowsky, Henrik
  • Hong, Johnny C
  • Busuttil, Ronald W
  • Kupiec-Weglinski, Jerzy W
Type
Published Article
Journal
Nature Reviews Gastroenterology & Hepatology
Publisher
Springer Nature
Publication Date
Feb 01, 2013
Volume
10
Issue
2
Pages
79–89
Identifiers
DOI: 10.1038/nrgastro.2012.225
PMID: 23229329
Source
Medline
License
Unknown

Abstract

Ischaemia-reperfusion injury (IRI) in the liver, a major complication of haemorrhagic shock, resection and transplantation, is a dynamic process that involves the two interrelated phases of local ischaemic insult and inflammation-mediated reperfusion injury. This Review highlights the latest mechanistic insights into innate-adaptive immune crosstalk and cell activation cascades that lead to inflammation-mediated injury in livers stressed by ischaemia-reperfusion, discusses progress in large animal experiments and examines efforts to minimize liver IRI in patients who have received a liver transplant. The interlinked signalling pathways in multiple hepatic cell types, the IRI kinetics and positive versus negative regulatory loops at the innate-adaptive immune interface are discussed. The current gaps in our knowledge and the pathophysiology aspects of IRI in which basic and translational research is still required are stressed. An improved appreciation of cellular immune events that trigger and sustain local inflammatory responses, which are ultimately responsible for organ injury, is fundamental to developing innovative strategies for treating patients who have received a liver transplant and developed ischaemia-reperfusion inflammation and organ dysfunction.

Report this publication

Statistics

Seen <100 times