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Optical Assessment of Nociceptive TRP Channel Function at the Peripheral Nerve Terminal.

Authors
  • Aleixandre-Carrera, Fernando1
  • Engelmayer, Nurit2, 3
  • Ares-Suárez, David1
  • Acosta, María Del Carmen1
  • Belmonte, Carlos1
  • Gallar, Juana1, 4
  • Meseguer, Víctor1
  • Binshtok, Alexander M2, 3
  • 1 Instituto de Neurociencias, Universidad Miguel Hernández-CSIC, 03550 San Juan de Alicante, Spain. , (Spain)
  • 2 Department of Medical Neurobiology, Institute for Medical Research Israel-Canada, Hadassah School of Medicine, The Hebrew University, Jerusalem 91123, Israel. , (Canada)
  • 3 The Edmond and Lily Safra Center for Brain Sciences, The Hebrew University of Jerusalem, Jerusalem 9190401, Israel. , (Israel)
  • 4 Instituto de Investigación Sanitaria y Biomédica de Alicante, 03550 San Juan de Alicante, Spain. , (Spain)
Type
Published Article
Journal
International Journal of Molecular Sciences
Publisher
MDPI AG
Publication Date
Jan 06, 2021
Volume
22
Issue
2
Identifiers
DOI: 10.3390/ijms22020481
PMID: 33418928
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Free nerve endings are key structures in sensory transduction of noxious stimuli. In spite of this, little is known about their functional organization. Transient receptor potential (TRP) channels have emerged as key molecular identities in the sensory transduction of pain-producing stimuli, yet the vast majority of our knowledge about sensory TRP channel function is limited to data obtained from in vitro models which do not necessarily reflect physiological conditions. In recent years, the development of novel optical methods such as genetically encoded calcium indicators and photo-modulation of ion channel activity by pharmacological tools has provided an invaluable opportunity to directly assess nociceptive TRP channel function at the nerve terminal.

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