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Iron transport machinery of human cells: players and their interactions.

Authors
  • Zhao, Ningning1
  • Enns, Caroline A
  • 1 Department of Cell and Developmental Biology, Oregon Health & Sciences University, Oregon, USA.
Type
Published Article
Journal
Current topics in membranes
Publication Date
Jan 01, 2012
Volume
69
Pages
67–93
Identifiers
DOI: 10.1016/B978-0-12-394390-3.00003-3
PMID: 23046647
Source
Medline
License
Unknown

Abstract

Organisms, like cells, maintain tight control of iron. In humans as well as other mammals, control is achieved through the regulation of iron uptake into the body rather than through the excretion of iron. The mechanisms by which humans and mice regulate both iron uptake and the distribution of iron within the body and cells are reviewed. Special emphasis is given to the iron transporters involved in this process.

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