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Iron(III) complexes: preparation, characterization, antibacterial activity and DNA-binding.

Authors
  • Pansuriya, Pramod B
  • Patel, M N
Type
Published Article
Journal
Journal of enzyme inhibition and medicinal chemistry
Publication Date
Apr 01, 2008
Volume
23
Issue
2
Pages
230–239
Identifiers
DOI: 10.1080/14756360701474657
PMID: 18343909
Source
Medline
License
Unknown

Abstract

Iron(III) have been combined to well known quinolones (ciprofloxacin) and some Schiff bases with the help of coordination approach. Characterization of these compounds have been done using elemental analysis, magnetic measurements, thermogravimetric analysis, IR, UV-VIS, (1)H NMR and (13)C NMR spectral investigation. Analytical studies suggest that the iron(III)-quinolone complexes assume a six-coordinated dimeric distorted octahedral geometry. All the compounds show a good antibacterial activity against broad range of bacteria like Bacillus cereus, Staphylococcus aureus, Escherichia coli, Bacillus subtilis, Salmonella typhi and Serratia marcescens, whereas no significant inhibition towards growth of fungal strains like Aspergillus Niger, Aspergillus flavus and Lasiodiplodia theobromae. Analyses of all these compounds show effective sperm herring DNA inhibition.

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