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Iron ERRs with Salmonella

Journal
Cell Host & Microbe
Publisher
Elsevier
Publication Date
May 14, 2014
Volume
15
Issue
5
Identifiers
DOI: 10.1016/j.chom.2014.04.012
License
Unknown

Abstract

The hormone hepcidin promotes iron sequestration by macrophages. A recent study by Kim et al. (2014) implicates the orphan receptor ERRγ (estrogen-related receptor γ) in the regulation of hepcidin production and suggests that targeting the ERRγ-hepcidin axis may be beneficial during infection with the facultative intracellular pathogen Salmonella.

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