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Iron Acquisition Mechanisms: Promising Target Against Mycobacterium tuberculosis.

Authors
  • Hameed, Saif
  • Pal, Rahul
  • Fatima, Zeeshan
Type
Published Article
Journal
The Open Microbiology Journal
Publisher
Bentham Science
Publication Date
Jan 01, 2015
Volume
9
Pages
91–97
Identifiers
DOI: 10.2174/1874285801509010091
PMID: 26464608
Source
Medline
Keywords
License
Unknown

Abstract

Continuous deployment of antitubercular drugs in treating Tuberculosis (TB) caused by Mycobacterium tuberculosis (MTB) has led to the emergence of drug resistance resulting in cross-resistance to many unrelated drugs, a phenomenon termed as Multi-Drug Resistance (MDR-TB). Despite reasonable documentation of major factors which contribute to MDR mechanisms, it appears unavoidable to consider novel mechanisms combating MDR. The ability of pathogenic MTB, to sense and become accustomed to changes in the host environment is essential for its survival and confers the basis of their success as dreadful pathogen. One such significant environmental factor that MTB must surmount is iron limitation, since they encounter diverse anatomical sites during the establishment of infection within the host. Considering the importance of MTB, being the second most common cause of mortality, this review focuses on gaining insights of iron acquisition mechanisms in MTB and how it can be exploited as efficient anti-mycobacterial drug target.

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