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Irisin, Energy Homeostasis and Male Reproduction

Authors
  • Sengupta, Pallav1
  • Dutta, Sulagna2
  • Karkada, Ivan Rolland1
  • Akhigbe, Roland Eghoghosoa3, 4
  • Chinni, Suresh V.5
  • 1 Physiology Unit, Faculty of Medicine, Bioscience and Nursing, MAHSA University, Kuala Lumpur , (Malaysia)
  • 2 Department of Oral Biology and Biomedical Sciences, Faculty of Dentistry, MAHSA University, Kuala Lumpur , (Malaysia)
  • 3 Department of Physiology, Ladoke Akintola University of Technology, Ogbomoso , (Nigeria)
  • 4 Reproductive Biology and Toxicology Research Laboratories, Oasis of Grace Hospital, Osogbo , (Nigeria)
  • 5 Department of Biotechnology, Faculty of Applied Sciences, AIMST University, Bedong , (Malaysia)
Type
Published Article
Journal
Frontiers in Physiology
Publisher
Frontiers Media SA
Publication Date
Sep 21, 2021
Volume
12
Identifiers
DOI: 10.3389/fphys.2021.746049
PMCID: PMC8490744
Source
PubMed Central
Keywords
Disciplines
  • Physiology
  • Mini Review
License
Unknown

Abstract

Irisin is a novel skeletal muscle- and adipose tissue-secreted peptide. It is conventionally regarded as an adipomyokine and is a cleaved fragment of Fibronectin type III domain-containing protein 5 (FNDC5). It is involved in the browning of white adipose tissue, glucose tolerance, and reversing of metabolic disruptions. Fertility is closely linked to energy metabolism and the endocrine function of the adipose tissue. Moreover, there is established association between obesity and male infertility. Irisin bears strong therapeutic promise in obesity and its associated disorders, as well as shown to improve male reproductive functions. Thus, irisin is a molecule of great interest in exploring the amelioration of metabolic syndrome or obesity-induced male infertility. In this review we aim to enumerate the most significant aspects of irisin actions and discuss its involvement in energy homeostasis and male reproduction. Though current and future research on irisin is very promiscuous, a number of clarifications are still needed to reveal its full potential as a significant medicinal target in several human diseases including male infertility.

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