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IRAP Inhibitors: M1-Aminopeptidase Family Inspiration

Authors
  • Barlow, Nicholas
  • Thompson, Philip E.
Type
Published Article
Journal
Frontiers in Pharmacology
Publisher
Frontiers Media SA
Publication Date
Sep 25, 2020
Volume
11
Identifiers
DOI: 10.3389/fphar.2020.585930
PMID: 33101040
PMCID: PMC7546331
Source
PubMed Central
Keywords
License
Unknown

Abstract

The insulin regulated aminopeptidase (IRAP) has been proposed as an important therapeutic target for indications including Alzheimer’s disease and immune disorders. To date, a number of IRAP inhibitor designs have been investigated but the total number of molecules investigated remains quite small. As a member the M1 aminopeptidase family, IRAP shares numerous structural features with the other M1 aminopeptidases. The study of those enzymes and the development of inhibitors provide key learnings and new approaches and are potential sources of inspiration for future IRAP inhibitors.

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