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Ipomoeassin-F inhibits the in vitro biogenesis of the SARS-CoV-2 spike protein and its host cell membrane receptor

Authors
  • O'Keefe, Sarah1
  • Roboti, Peristera1
  • Duah, Kwabena B.2
  • Zong, Guanghui3
  • Schneider, Hayden2
  • Shi, Wei Q.2
  • High, Stephen1
  • 1 University of Manchester, Faculty of Biology, Medicine and Health, Manchester M13 9PT
  • 2 Ball State University, Department of Chemistry, Muncie, IN 47306
  • 3 University of Maryland, Department of Chemistry and Biochemistry, College Park, MD 20742
Type
Published Article
Journal
Journal of Cell Science
Publisher
The Company of Biologists
Publication Date
Feb 19, 2021
Volume
134
Issue
4
Identifiers
DOI: 10.1242/jcs.257758
PMID: 33468620
PMCID: PMC7904091
Source
PubMed Central
Keywords
License
Green

Abstract

Summary: Ipomoeassin-F blocks the Sec61-dependent translocation of SARS-CoV-2 proteins into and across the endoplasmic reticulum, highlighting the potential of Sec61 inhibitors as antiviral agents.

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