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Ion-Molecular Reactions of Esters of Carbocyclic Alcohols in a Direct Analysis in Real Time (DART) Mass Spectrometer

Authors
  • Goriainov, S. V.1, 2
  • Esparza, C.2
  • Zhilyaev, D. I.1, 2
  • Polovkov, N. Yu.1
  • Borisov, R. S.1, 2
  • Zaikin, V. G.1
  • 1 Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences, Moscow, 119991, Russia , Moscow (Russia)
  • 2 RUDN University, Moscow, 117198, Russia , Moscow (Russia)
Type
Published Article
Journal
Journal of Analytical Chemistry
Publisher
Pleiades Publishing
Publication Date
Dec 22, 2021
Volume
76
Issue
14
Pages
1618–1623
Identifiers
DOI: 10.1134/S1061934821140057
Source
Springer Nature
Keywords
Disciplines
  • Articles
License
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Abstract

AbstractWe studied the interaction of acyl derivatives of carbocyclic alcohols of steroid structure with nitrogenous bases in the ion source of a “direct analysis in real time” (DART) mass spectrometer. The protonation of esters in the DART plasma is accompanied by the elimination of a corresponding acid (acyl derivatives of cholesterol, β-sitosterol, and estradiol), interaction of the formed cation with a nitrogenous base to yield a derivative with a bound charge. This effect was not observed for cortisone acetate and betamethasone dipropionate, which is consistent with the absence of ions of deacyl derivatives in their DART mass spectra.

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