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Ionization Neutralizes the Allergy-Inducing Property of 3-Pentadecylcatechol: A Urushiol Derivative.

Authors
  • Jeong, Hang Yeon1
  • Lee, Tae Ho1
  • Lee, Hyoung Jae1
  • Cho, Jeong-Yong1
  • Moon, Jae-Hak1
  • 1 Department of Food Science and Technology, Chonnam National University, Gwangju, Republic of Korea. , (North Korea)
Type
Published Article
Journal
Journal of Medicinal Food
Publisher
Mary Ann Liebert
Publication Date
Jul 01, 2020
Volume
23
Issue
7
Pages
793–801
Identifiers
DOI: 10.1089/jmf.2019.4510
PMID: 32380887
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Urushiols are amphipathic compounds found in Rhus verniciflua Stokes that exhibit various biological activities. However, their practical use is very restricted due to their contact dermatitis-inducing property. Therefore, we applied the ionization method to remove the allergenic properties of the urushiols and to increase their usability. One of the natural urushiols, 3-pentadecylcatechol (PDC), was heated for 30 min with a solution of H2O and sodium carbonate (Na2CO3). The reaction product was analyzed by electrospray ionization mass spectrometry (ESI-MS). Ionized PDC with an m/z value of 316.9 and complexed PDCs with Na+ of 1 - 3 atoms with m/z values of 340.8, 365.2, and 380.8 were detected. PDC and ionized PDC (3 μmol/3 mg of Vaseline) treatments were applied on the rear of left ear of Sprague-Dawley rats once daily for 10 days. Erythema and swelling were observed on the ear skin treated with PDC, but not in case of ionized PDC. Compared with control, contact hypersensitivity-related biomarkers (neutrophils, eosinophils, immunoglobulin E, and histamine) in the blood were significantly higher only in the PDC-treated group. In addition, Il-1b, Il-6, Tnfα, and Cox-2 mRNA expression levels were dramatically increased in the ear tissue of PDC-treated rats, but in the ionized PDC-treated group, they were similar to those in the control group. Overall, it was confirmed that the allergenic property of the urushiol PDC was removed by ionization. This method is expected to be useful for preventing allergy induction in cooking and food processing using R. verniciflua Stokes.

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