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Ionic liquids as water-compatible GC stationary phases for the analysis of fragrances and essential oils: Quantitative GC-MS analysis of officially-regulated allergens in perfumes.

Authors
  • Mazzucotelli, Maria1
  • Minteguiaga, Manuel A2
  • Sgorbini, Barbara1
  • Sidisky, Len3
  • Marengo, Arianna1
  • Rubiolo, Patrizia1
  • Bicchi, Carlo1
  • Cagliero, Cecilia4
  • 1 Dipartimento di Scienza e Tecnologia del Farmaco, Università degli Studi di Torino, Via P. Giuria 9, I-10125 Torino, Italy. , (Italy)
  • 2 Dipartimento di Scienza e Tecnologia del Farmaco, Università degli Studi di Torino, Via P. Giuria 9, I-10125 Torino, Italy; Laboratorio de Biotecnología de Aromas, Departamento de Química Orgánica, Facultad de Química, Universidad de la República, General Flores 2124, Montevideos, 11800, Uruguay. , (Italy)
  • 3 MilliporeSigma 595 N. Harrison Rd., Bellefonte, PA, 16823, USA.
  • 4 Dipartimento di Scienza e Tecnologia del Farmaco, Università degli Studi di Torino, Via P. Giuria 9, I-10125 Torino, Italy. Electronic address: [email protected] , (Italy)
Type
Published Article
Journal
Journal of chromatography. A
Publication Date
Oct 05, 2019
Pages
460567–460567
Identifiers
DOI: 10.1016/j.chroma.2019.460567
PMID: 31629492
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Qualitative and quantitative determination of volatile markers in aqueous based fragrances assumes ever-increasing importance, because of both the need for quality control and the safety-regulatory limitations introduced for several compounds. This study reports and critically discusses the results of applying new water-compatible ionic-liquid (IL) GC stationary phases, based on phosphonium and imidazolium derivative cations combined with trifluoromethanesulphonate (Watercol™) to the direct quantitative analysis of aqueous samples in the perfume field with GC-MS. Narrow-bore columns of different lengths, especially prepared for this study, were adopted to minimize the amount of water reaching the MS detector after GC separation. All GC-MS analysis steps were investigated, to achieve results compatible with quality control requirements for the volatiles of interest in this field, in terms of LODs, LOQs, and repeatability. Reliability of the GC-MS results was demonstrated by determining volatile allergens in two commercial perfumes, as per EU regulations concerning no-declaration limits for leave-on (0.001%) and rinse-off (0.01%) cosmetic products. Copyright © 2019 Elsevier B.V. All rights reserved.

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