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[Ion channels, induced by amphotericin B introduced unilaterally into lipid bilayers].

Authors
  • Brutian, R A
Type
Published Article
Journal
Biofizika
Publication Date
Jan 01, 1982
Volume
27
Issue
4
Pages
646–649
Identifiers
PMID: 6289919
Source
Medline
License
Unknown

Abstract

Single ionic channels of approximately 10 pS in magnitude and approximately 100 ms duration (in 2 M KCl solution) were recorded when amphotericin B (AB) was added to one side of a lipid bilayer. Using blocking ions it has been shown that these channels are asymmetrical half-pores (similar to those postulated by Marty and Finkelstein) which are capable of forming long-living symmetrical pores if AB is added to both sides of the membrane.

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