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Iodine-125-labeled triiodothyronine in rat brain: evidence for localization in discrete neural systems.

Authors
  • Dratman, M B
  • Futaesaku, Y
  • Crutchfield, F L
  • Berman, N
  • Payne, B
  • Sar, M
  • Stumpf, W E
Type
Published Article
Journal
Science (New York, N.Y.)
Publication Date
Jan 15, 1982
Volume
215
Issue
4530
Pages
309–312
Identifiers
PMID: 7053582
Source
Medline
License
Unknown

Abstract

Autoradiograms prepared from adult rat brains demonstrate that nerve cells and neuropil in different brain regions selectively concentrate and retain intravenously administered triiodothyronine, by mechanisms susceptible to saturation with excess triiodothyronine. A neuroregulatory role for thyroid hormones, strongly supported by the observations, may account for their marked effects on behavior and the activity of the autonomic nervous system.

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