Involvement of tryptase-related cellular protease(s) in human immunodeficiency virus type 1 infection.
- Published Article
Wiley (John Wiley & Sons)
- Publication Date
May 08, 1989
Trypstatin, a new cellular Kunitz-type protease inhibitor purified from rat mast cells, inhibited syncytium formation in human immunodeficiency virus type 1 (HIV-1)-infected CCRF-CEM and uninfected Molt-4 clone 8 at a concentration of 1 microM. Anti-rat tongue mast cell tryptase antibodies reacted with Molt-4 clone 8 cells, as determined by Western blot and by immunofluorescence. In addition, the antibody inhibited syncytium formation. These findings along with homologous sequences with trypstatin and a neutralizing epitope of gp120 of HIV-1 suggest that a tryptase-like cellular enzyme(s) is involved in HIV-1 infection.
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The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/2470618