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Involvement of protein kinase C in signal transduction during fibroblast chemotaxis to platelet-derived growth factor and a fragment of fibronectin.

Authors
  • Adelmann-Grill, B C
  • Wach, F
  • Behr, J
  • Krieg, T
Type
Published Article
Journal
European Journal of Cell Biology
Publisher
Elsevier
Publication Date
Oct 01, 1989
Volume
50
Issue
1
Pages
128–131
Identifiers
PMID: 2612499
Source
Medline
License
Unknown

Abstract

The involvement of protein kinase C in chemotaxis of normal dermal fibroblasts to a mitogenic and a non-mitogenic attractant was investigated. Neomycin, an inhibitor of phosphoinositide metabolism, H7, staurosporine, and sphingosine, inhibitors of protein kinase C, as well as amiloride, an inhibitor of the Na+/H+-antiport, all abrogated chemotaxis of fibroblasts to platelet-derived growth factor and to a chemotactically active fragment of fibronectin. Down-regulation of protein kinase C by phorbol ester likewise diminished the capacity of fibroblasts to move directionally to these attractants. Therefore, all three of these signal transduction steps are required for the chemotactic response of this type of cells.

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