Involvement of lysosomal exocytosis in the excretion of mesoporous silica nanoparticles and enhancement of the drug delivery effect by exocytosis inhibition.
- Authors
- Type
- Published Article
- Journal
- Small Group Research
- Publisher
- SAGE Publications
- Publication Date
- Nov 12, 2012
- Volume
- 9
- Issue
- 5
- Pages
- 697–704
- Identifiers
- DOI: 10.1002/smll.201201811
- PMID: 23152124
- PMCID: PMC3767416
- Source
- AIMS
- Keywords
- License
- Green
Abstract
The exocytosis of phosphonate modified mesoporous silica nanoparticles (P-MSNs) is demonstrated and lysosomal exocytosis is identified as the mechanism responsible for this event. Regulation of P-MSN exocytosis can be achieved by inhibiting or accelerating lysosomal exocytosis. Slowing down P-MSN exocytosis enhances the drug delivery effect of CPT-loaded P-MSNs by improving cell killing.
