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Involvement of Mast Cells in the Pathophysiology of Pain

Authors
  • Mai, Lijia1, 2
  • Liu, Qing1, 2
  • Huang, Fang2
  • He, Hongwen2
  • Fan, Wenguo1, 2
  • 1 Department of Anesthesiology, Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University, Guangzhou , (China)
  • 2 Guangdong Provincial Key Laboratory of Stomatology, Institute of Stomatological Research, Sun Yat-sen University, Guangzhou , (China)
Type
Published Article
Journal
Frontiers in Cellular Neuroscience
Publisher
Frontiers Media SA
Publication Date
Jun 10, 2021
Volume
15
Identifiers
DOI: 10.3389/fncel.2021.665066
Source
Frontiers
Keywords
Disciplines
  • Cellular Neuroscience
  • Mini Review
License
Green

Abstract

Mast cells (MCs) are immune cells and are widely distributed throughout the body. MCs are not only classically viewed as effector cells of some allergic diseases but also participate in host defense, innate and acquired immunity, homeostatic responses, and immunoregulation. Mounting evidence indicates that activation of MCs releasing numerous vasoactive and inflammatory mediators has effects on the nervous system and has been involved in different pain conditions. Here, we review the latest advances made about the implication of MCs in pain. Possible cellular and molecular mechanisms regarding the crosstalk between MC and the nervous system in the initiation and maintenance of pain are also discussed.

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