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Involvement of a forkhead transcription factor, FOXO1A, in UV-induced changes of collagen metabolism.

Authors
  • Tanaka, Hiroshi1
  • Murakami, Yuhko
  • Ishii, Izumi
  • Nakata, Satoru
  • 1 Research Laboratories, Nippon Menard Cosmetic Co. Ltd, Nagoya, Japan. [email protected] , (Japan)
Type
Published Article
Journal
Journal of Investigative Dermatology Symposium Proceedings
Publisher
Elsevier
Publication Date
Aug 01, 2009
Volume
14
Issue
1
Pages
60–62
Identifiers
DOI: 10.1038/jidsymp.2009.2
PMID: 19675556
Source
Medline
License
Unknown

Abstract

Transcription factors belonging to the forkhead box gene, group O (FOXOs) family have been found to be crucial in downstream suppression of life-shortening effects of the insulin/insulin-like growth factor-1 (IGF-1) signaling pathway, which accelerates aging by suppressing FOXOs. Thus, FOXOs could hold the key for counteracting aging. Although FOXOs may play a critical role in aging, the effects of FOXOs on UV-induced changes of collagen metabolism by dermal fibroblasts are unknown. In this study, UV-induced changes in FOXO1a expression and the roles of FOXO1a in the regulation of collagen synthesis and matrix metalloproteinase (MMPs) expression in human dermal fibroblasts were investigated. In UVA- or UVB-irradiated fibroblasts, the expression of FOXO1A mRNA decreased significantly. The expression of type I collagen (COLIAI) also decreased. On the other hand, MMP-1 and MMP-2 mRNA levels increased. FOXO1A-small interfering RNA transfection induced the downregulation of FOXO1A expression, it also induced a decrease in COLIAI expression, and it increased MMP-1 and MMP-2 expression. These changes are similar to those observed in UV-irradiated fibroblasts. Furthermore, FOXO1a-peptide induced opposite changes in COLIAI, MMP-1, and MMP-2 expression. Therefore, FOXO1a is involved in the UV-induced changes of type I collagen and MMPs expression.Journal of Investigative Dermatology Symposium Proceedings (2009) 14, 60-62; doi:10.1038/jidsymp.2009.2.

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