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Investigation of TNF-α and IL-6 Levels in the Sera of Non-Melanoma Skin Cancer Patients

Authors
  • Ghahartars, Mehdi1
  • Abtahi, Shabnam2
  • Zeinali, Zahra2
  • Fattahi, Mohammad Javad2
  • Ghaderi, Abbas2, 3
  • 1 Department of Dermatology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran;
  • 2 Shiraz Institute for Cancer Research, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran,
  • 3 Department of Immunology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
Type
Published Article
Journal
Iranian Biomedical Journal
Publisher
Pasteur Institute of Iran
Publication Date
Sep 01, 2020
Volume
25
Issue
2
Pages
88–92
Identifiers
DOI: 10.29252/ibj.25.2.88
PMID: 33461943
PMCID: PMC7921522
Source
PubMed Central
Keywords
Disciplines
  • Full Length
License
Green

Abstract

Background: TNF-α and IL-6 are both pleiotropic cytokines playing major roles in cancer-associated cytokine networks. They have previously been investigated for their function in skin malignancies, mostly melanomas, and studies on NMSC patients are relatively rare. In this study, we aimed to assess the associations of serum levels of IL-6 and TNF-α with NMSCs and its clinicopathological features. Methods: This cases-control study was carried out to investigate the serum levels of TNF-α and IL-6 in 70 NMSC patients, in comparison with 30 healthy individuals, by means of flow cytometric bead-based immuneoassay. Results: Serum levels of both TNF-α and IL-6 were significantly higher in NMSC patients (6.470 vs. 4.355 pg/ml; p = 0.0468, respectively), compared to healthy individuals (3.205 vs. 0.000 pg/ml; p = 0.0126, respectively). In the subgroup analysis, SCC patients had higher serum levels of IL-6 compared to healthy individuals (3.445 vs. 0.000 pg/ml; p = 0.0432). No other significant differences were observed in the serum levels of these two cytokines among different clinicopathological subgroups of the patients. Conclusion: The increased levels of TNF-α and IL-6 in NMSC patients can be introduced as an epiphenomenon of a complex cancer-induced cytokine cascade.

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