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Investigation of SARS-CoV-2 Epsilon Variant and Hospitalization Status by Genomic Surveillance in a Single Large Health System During the 2020-2021 Winter Surge in Southern California.

Authors
  • Yang, Shangxin1
  • Hemarajata, Peera2
  • Hilt, Evann E1
  • Price, Travis K1
  • Garner, Omai B1
  • Green, Nicole M2
  • 1 Department of Pathology and Laboratory Medicine, UCLA David Geffen School of Medicine, Los Angeles, CA, USA.
  • 2 Los Angeles Department of Public Health, Downey, CA, USA.
Type
Published Article
Journal
American Journal of Clinical Pathology
Publisher
Oxford University Press
Publication Date
May 04, 2022
Volume
157
Issue
5
Pages
649–652
Identifiers
DOI: 10.1093/ajcp/aqab203
PMID: 34875004
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

This study aimed to assess whether the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Epsilon variant (B.1.429/427) is more virulent, leading to more hospitalization and more severe disease requiring intensive care unit (ICU) admission. SARS-CoV-2 genomic surveillance was performed on respiratory samples from 231 unique patients, collected at a single large health system in Southern California between November 2020 and March 2021 during the winter surge. The frequencies of the Epsilon variant among outpatients, hospitalized patients, and ICU patients were indifferent. Our study suggests that the Epsilon variant is not associated with increased hospitalization and ICU admission. © American Society for Clinical Pathology, 2021. All rights reserved. For permissions, please e-mail: [email protected]

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