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Investigation of the relationship between inherited thrombophilia and novel coronavirus pneumonia

Authors
  • Kiraz, Aslihan1
  • Guzeldag, Seda2
  • Eren, Esma1
  • Goksu, Musa1
  • Bayram, Arslan3
  • 1 38080, Turkey
  • 2 Intensive Care Unit, Kayseri City Education & Research Hospital, Kayseri 38080, Turkey
  • 3 06010, Turkey
Type
Published Article
Journal
Future Virology
Publisher
Future Medicine
Publication Date
Apr 21, 2021
Identifiers
DOI: 10.2217/fvl-2020-0395
PMCID: PMC8059147
Source
PubMed Central
Keywords
Disciplines
  • Short Communication
License
Unknown

Abstract

Aim: This study aimed to investigate the relationship between severe novel coronavirus pneumonia (NCP) and hypercoagulable conditions that predispose patients to thrombosis such as the prothrombin gene ( F2 ) rs1799963 (G20210A), factor V Leiden ( F5 ) rs6025 (G1691A) and PAI-1 (rs1799768). Patients: NCP-diagnosed 62 previously healthy patients were enrolled for the investigation of the thrombophilia-related polymorphisms. Materials & methods: The frequency of genotypes were compared with healthy control group frequencies from other studies. Results: There were no statistically significant differences between the severe patient group and the healthy population regarding the investigated single nucleotide polymorphisms (SNPs). Conclusion: This study is the first to rule out the relationship of rs1799963, rs6025 and rs1799768 with severe NCP.

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