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Investigation of the Protective Effect of Nigella Sativa Oil in Cisplatin Induced Oral Mucositis: An Experimental Study.

Authors
  • Eğilmez, Oğuz Kadir1
  • Kökten, Numan2
  • Kalcıoğlu, Mahmut Tayyar2
  • Ekici, Asiye Işın Doğan3
  • Şerifler, Serkan2
  • Yeşilada, Erdem4
  • 1 Department of Otorhinolaryngology, Sakarya University Training and Research Hospital, Sakarya, Turkey. , (Turkey)
  • 2 Department of Otorhinolaryngology, İstanbul Medeniyet University Göztepe Training and Research Hospital, İstanbul, Turkey. , (Turkey)
  • 3 Department of Pathology, Yeditepe University School of Medicine, İstanbul, Turkey. , (Turkey)
  • 4 Department of Pharmacognosy, Yeditepe University School of Pharmacy, İstanbul, Turkey. , (Turkey)
Type
Published Article
Journal
Turkish archives of otorhinolaryngology
Publication Date
Mar 01, 2020
Volume
58
Issue
1
Pages
10–15
Identifiers
DOI: 10.5152/tao.2020.4733
PMID: 32313889
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

The aim of this experimental study was to investigate the histopathologic effect of Nigella Sativa oil (NSO) on cisplatin (Cis) induced oral mucositis (OM) in rats. Twenty-four rats were divided into four equal groups. The animals in Group 1 and Group 2 were given 5 mg/kg intraperitoneal (ip) Cis systemically on the 1st, 3rd and 5th days of the study. Additionally, 15 mL NSO were given to the rats in Group 2, with gavage feeding on days 1, 3, 5, 7, and 9. The animals in Group 3 were given per oral 15 ml NSO on days 1, 3, 5, 7 and 9. As the control group, Group 4 received a total of 15 mL 0.9% saline solution divided into 5 doses on days 1, 3, 5, 7 and 9 by oral gavage. On the 14th day, animals were euthanized and buccal mucosa from both sides, including submucosal tissues, were excised and taken to histopathological examination. The mean mucosal thicknesses of the groups were 224.58 μm, 276.1 μm, 323.33 μm, and 331.33 μm, respectively for Groups 1, 2, 3, and 4 (p<0.05). When the degree of mucosal inflammation was examined, the most intense inflammation was detected in Group 1 and the least intense inflammation was in Group 4 (p<0.01). The degree of inflammation in Group 2 and Group 3 were similar to Group 4 (p>0.05). According to the results of this study, NSO, for which anti-inflammatory and antioxidant properties have been shown in previous studies, may also be effective in preventing Cis-induced OM. © Copyright 2020 by Official Journal of the Turkish Society of Otorhinolaryngology and Head and Neck Surgery.

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