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Investigation of photo-induced electron transfer between amino-functionalized graphene quantum dots and selenium nanoparticle and it's application for sensitive fluorescent detection of copper ions.

Authors
  • Li, Yi1
  • Zhang, Weilu1
  • Jiang, Xiangmei1
  • Kou, Yanxia1
  • Lu, Jiajia1
  • Tan, Liang2
  • 1 Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research (Ministry of Education of China), College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha 410081, PR China. , (China)
  • 2 Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research (Ministry of Education of China), College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha 410081, PR China. Electronic address: [email protected] , (China)
Type
Published Article
Journal
Talanta
Publication Date
May 15, 2019
Volume
197
Pages
341–347
Identifiers
DOI: 10.1016/j.talanta.2019.01.036
PMID: 30771945
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Copper ions play an essential role in some biological processes. Currently, there is a need for the development of convenient and reliable analytical methods for the Cu2+ measurement. In the present work, a sensitive fluorescence method was developed for the determination of copper ions. Amino-functionalized graphene quantum dots (af-GQDs) and selenium nanoparticles (Se NPs) were synthetized, respectively, and they were characterized via transmission electron microscope, infrared spectrum analysis and X-ray photoelectron spectrum measurement. Photo-induced electron transfer (PET) between the prepared two nanomaterials could effectively quench the fluorescence of af-GQDs. Cu(II) was reduced to Cu(I) in the presence ascorbic acid and Cu2Se was finally generated on Se NPs surface, which led to the declined PET efficiency and inhibited the fluorescence quenching of af-GQDs. The change in fluorescence intensity was linearly correlated to the logarithm of the Cu2+ concentration from 1 nM to 10 μM, with a detection limit of 0.4 nM under the optimal conditions. The detections of copper ions in water samples were realized via standard addition method and the recovery values varied from 98.7% to 103%. The proposed fluorescence method was also employed to analyze the uptake of Cu2+ into human cervical carcinoma HeLa cells and cisplatin-resistant HeLa cells (HeLa/DDP cells). The experimental results indicate that the decreased hCTR1 expression level in HeLa/DDP cells weakened the uptake of copper ions into these drug-resistant tumor cells. Copyright © 2019 Elsevier B.V. All rights reserved.

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