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Investigation of nanoscale structural alterations of cell nucleus as an early sign of cancer.

Authors
  • Liu, Yang
  • Uttam, Shikhar
  • Alexandrov, Sergey
  • Bista, Rajan K
Type
Published Article
Journal
BMC biophysics
Publication Date
Jan 01, 2014
Volume
7
Issue
1
Pages
1–1
Identifiers
DOI: 10.1186/2046-1682-7-1
PMID: 24507508
Source
Medline
License
Unknown

Abstract

The analysis of nanoscale structural characteristics has shown promise in detecting cancer before the microscopically visible changes become evident and proof-of-concept studies have shown its feasibility as an earlier or more sensitive marker for cancer detection or diagnosis. Further biophysical investigation of specific 3D nanoscale structural characteristics in carcinogenesis, especially with well-annotated human cells and tissue, is much needed in cancer research.

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