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[Investigation of mutations of BRCA1 and BRCA2 genes in 52 breast cancer patients].

Authors
  • Tereshchenko, I V
  • Béshém, V M
  • Slonimskaia, E M
  • Ponder, B A
  • Férokh, P D
  • Velichko, S A
  • Shagiakhmetova, R A
Type
Published Article
Journal
Voprosy onkologii
Publication Date
Jan 01, 2002
Volume
48
Issue
1
Pages
24–28
Identifiers
PMID: 12101561
Source
Medline
License
Unknown

Abstract

The proportion of BRCA1/2 genes varies widely among populations. We investigated 52 cases of breast cancer: 24 cases of familial breast cancer, 22--early-onset (till 40 years) and 6--bilateral cancer. The frequency of carriers of mutations among familial cancer cases was 16%, among cases of disease till 40 years--9%. 538insC BRCA1 was the most common genetic mutation among hereditary cases of breast cancer.

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