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Investigation of laser-induced choroidal neovascularization in the rat.

Authors
  • Semkova, Irina
  • Peters, Swaantje
  • Welsandt, Gerhard
  • Janicki, Hanna
  • Jordan, Jens
  • Schraermeyer, Ulrich
Type
Published Article
Journal
Investigative Ophthalmology & Visual Science
Publisher
Association for Research in Vision and Ophthalmology (ARVO)
Publication Date
Dec 01, 2003
Volume
44
Issue
12
Pages
5349–5354
Identifiers
PMID: 14638737
Source
Medline
License
Unknown

Abstract

In the rat model of laser-induced neovascularization, newly developed endothelial cells originate from the retina and the choroid. Whereas ring-like surrounding vessels come from the retina, flat endothelial cells in deeper layers are of choroidal origin or may originate from circulating endothelial precursor cells. Dextran angiography has to be regarded critically for visualizing the choriocapillaris and CNV in laser scars. PECAM-1 immunohistochemistry is best for detection and quantification of neovascularization in laser scars.

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