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Investigation of electrospray ionization and electrostatic focusing devices using a three-dimensional electrospray current density profiler.

Authors
  • Thompson, J Will
  • Eschelbach, John W
  • Wilburn, Richard T
  • Jorgenson, James W
Type
Published Article
Journal
Journal of the American Society for Mass Spectrometry
Publication Date
Mar 01, 2005
Volume
16
Issue
3
Pages
312–323
Identifiers
PMID: 15734324
Source
Medline
License
Unknown

Abstract

A novel instrument for profiling the current density of nanoelectrospray ionization plumes in three dimensions has been developed. A hemispherically-shaped electrostatic lens at atmospheric pressure is found to be able to compress the space-charge in nano-ESI and increase the average current density in the plume to three times the nominal value. Ion transmission into a single-quadrupole mass spectrometer is found to roughly double using the electrostatic lens. Data also suggest that ion transmission into the first vacuum region for a skimmer-type mass spectrometer interface using nano-ESI may be typically 40% or better with no special focusing device used.

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