The positive rate of Anti-HAV in 1663 general Guangzhou population were investigated by ELISA in 1988. The total positive rate of anti-HAV antibody ways 65.1%. There are great differences between the overall positive rate of anti-HAV antibody and those in different districts and counties. Among them, the highest rate was 90.2%, the lowest was 46.7%. The overall positive rate of anti-HAV antibody of rural population (79.3%) was significant higher than that of urban population (53.9%). The rates in scattered children (46.5%) were higher than in the organized children (20.8%). Among the less than 4 years old children, boys (39.0%) were higher than the girls (13.3%). Among 0-10 years old children, it presented a tendency of anti-HAV antibody rate from 15.4% to 44.4%, it increased rapidly to 29.73% in children aged 0-4. Among 10-49 years old group, the rate was going up with age. The value of the peak of positive rate of Anti-HAV antibody situated on 45-49 years of age, and after fifty the rate slowly decreased.