Affordable Access

deepdyve-link deepdyve-link
Publisher Website

Investigating the role of hypothalamic paraventricular nucleus in nociception of the rat.

Authors
Type
Published Article
Journal
The International journal of neuroscience
Publication Date
Volume
118
Issue
4
Pages
473–485
Identifiers
DOI: 10.1080/00207450601123563
PMID: 18322857
Source
Medline
License
Unknown

Abstract

The role of hypothalamic paraventricular nucleus (PVN) in nociception was investigated in the rat. Electrical stimulation of the PVN increased pain threshold, and microinjection of L-glutamate sodium into the PVN also elevated pain threshold in a dose-dependent manner, whereas cauterization of the PVN decreased pain threshold. Stimulation or cauterization of the area located within 1.0 mm of the outer perimeter of the PVN did not change pain threshold. Pituitary removal could not influence the effect of L-glutamate sodium microinjection into PVN-induced pain threshold increase. The data suggest that PVN plays a role in antinociception through the central nervous system rather than peripheral organs.

Statistics

Seen <100 times