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[Invertors--intracellular regulators of plasma membrane function].

Authors
Type
Published Article
Journal
Fiziolohichnyĭ zhurnal (Kiev, Ukraine : 1994)
Publication Date
Volume
45
Issue
1-2
Pages
6–15
Identifiers
PMID: 10202631
Source
Medline

Abstract

It has been found that the activation of protein biosynthesis in various cells (hepatocytes, adrenocorticocytes, thyrocytes and myocardiocytes), caused by different factors such as multiple hormones, regeneration, hyperfunction etc., leads to the development of plasmatic membrane hyperpolarization. It has also been shown that during protein biosynthesis activation under genome control there have been synthesized the intracellular regulators of plasmatic membrane state, called invertors. The invertors regulate the activity of membrane enzymes and ion channels, as well as adapt plasma membrane state to the needs of cell. With increasing age, the invertors synthesis alters, and this becomes an important genome-membraneous mechanism of aging. An experimental lifespan prolongation promotes to maintain the synthesis of invertors.

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