Inversely correlated expression of p16 and Rb protein in non-small cell lung cancers: an immunohistochemical study.
- Authors
- Type
- Published Article
- Journal
- International journal of cancer. Journal international du cancer
- Publication Date
- Feb 08, 1996
- Volume
- 65
- Issue
- 4
- Pages
- 442–445
- Identifiers
- PMID: 8621224
- Source
- Medline
- License
- Unknown
Abstract
Cdk4-mediated phosphorylation of Rb protein is inhibited by p16, a product of a possible tumor suppressor gene. We examined the expression of p16 and Rb protein by means of immunohistochemistry in 61 non-small cell lung cancers and have demonstrated an inverse relationship between the expression of p16 and Rb protein: 28/30 specimens that did not stain for p16 stained for Rb and 21/31 p16-positive specimens did not stain for Rb. Only 1 of the p16-negative specimens had a mutation of exon 2 of the CDKN2 gene. Our results indirectly support the theory that p16 expression is negatively regulated by the functional Rb protein.