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Inversely correlated expression of p16 and Rb protein in non-small cell lung cancers: an immunohistochemical study.

Authors
  • Sakaguchi, M
  • Fujii, Y
  • Hirabayashi, H
  • Yoon, H E
  • Komoto, Y
  • Oue, T
  • Kusafuka, T
  • Okada, A
  • Matsuda, H
Type
Published Article
Journal
International journal of cancer. Journal international du cancer
Publication Date
Feb 08, 1996
Volume
65
Issue
4
Pages
442–445
Identifiers
PMID: 8621224
Source
Medline
License
Unknown

Abstract

Cdk4-mediated phosphorylation of Rb protein is inhibited by p16, a product of a possible tumor suppressor gene. We examined the expression of p16 and Rb protein by means of immunohistochemistry in 61 non-small cell lung cancers and have demonstrated an inverse relationship between the expression of p16 and Rb protein: 28/30 specimens that did not stain for p16 stained for Rb and 21/31 p16-positive specimens did not stain for Rb. Only 1 of the p16-negative specimens had a mutation of exon 2 of the CDKN2 gene. Our results indirectly support the theory that p16 expression is negatively regulated by the functional Rb protein.

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