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Is invasion efficiency in malaria controlled by pre-invasion events?

Authors
Type
Published Article
Journal
Trends in Parasitology
1471-4922
Publisher
Elsevier
Publication Date
Volume
23
Issue
10
Pages
481–484
Identifiers
PMID: 17804296
Source
Medline
License
Unknown

Abstract

The invasion efficiency of Plasmodium falciparum merozoites was found to decrease with increasing red blood cell density, a finding relevant to protection strategies against falciparum malaria. The mechanism of this 'density effect' remained unexplained. Searching for possible explanations, we studied selected video recordings of the dynamic events during merozoite invasion and identified a pre-invasion stage as a crucial mediator of invasion efficiency. We suggest that the role of the pre-invasion stage is to induce the apical alignment of the merozoite, and propose a working hypothesis on its mechanism, with a crucial role for elevated intracellular Ca2+.

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