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An intron in the YRA1 gene is required to control Yra1 protein expression and mRNA export in yeast.

Authors
Type
Published Article
Journal
EMBO reports
Publication Date
Volume
3
Issue
5
Pages
438–442
Identifiers
PMID: 11964382
Source
Medline
License
Unknown

Abstract

Yra1p is an essential and conserved mRNA export factor in yeast. Strikingly, removal of the intron from YRA1 causes a dominant-negative growth phenotype and a concomitant inhibition of mRNA export. However, both defects are neutralized by replacement of the intron of YRA1 by a different intron. Significantly, Yra1p is overproduced in yeast when expressed from its intronless gene, but Yra1p levels are the same as the wild type when expressed from an intron-containing YRA1 gene. Thus, an intron in YRA1 controls Yra1p expression and mRNA export.

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