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Intravital-microscopic observations on the intravascular behavior of blood cell components during dietary-induced hyperlipidemia in the male rabbit.

Authors
  • Asano, M
  • Ohkubo, C
  • Hirokawa, A
  • Sasaki, A
  • Tochihara, Y
  • Chiba, Y
Type
Published Article
Journal
Biorheology
Publication Date
Jan 01, 1988
Volume
25
Issue
1-2
Pages
329–338
Identifiers
PMID: 3196830
Source
Medline
License
Unknown

Abstract

In normal male rabbits loaded dietary cholesterol, intravital-microscopy revealed a marked acceleration of intravascular adhesiveness of white blood cells and aggregability of red blood cells and a swarming of lipid-laden macrophages in connective tissue space concurrently with a systemic hyperlipidemia and anemia. Possible roles of the microcirculatory changes in the atherogenesis were discussed.

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